Finding and characterizing a catalytic antibody light chain, H34, capable of degrading the PD-1 molecule-Reference-Cited by-同舟云学术

Finding and characterizing a catalytic antibody light chain, H34, capable of degrading the PD-1 molecule

Published:2021 Issue:1 Volume:2 Page:220-229
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Hifumi Emi¹²³⁴^ORCID,Taguchi Hiroaki⁵⁶⁷⁴,Nonaka Tamami¹²³⁴,Harada Takunori¹⁸⁹³⁴^ORCID,Uda Taizo¹⁰¹¹¹²⁴

Affiliation:

1. Oita University

2. Research Promotion Institute

3. Oita 870-1192

4. Japan

5. Suzuka University of Medical Science

6. Faculty of Pharmaceutical Sciences

7. Suzuka 510-0293

8. Faculty of Science & Technology

9. Division of Applied Chemistry

10. Nanotechnology Laboratory

11. Institute of Systems, Information Technologies and Nanotechnologies (ISIT)

12. Fukuoka 879-5593

Abstract

Programmed cell death 1 (PD-1) is an immune checkpoint regulating T-cell function. A catalytic antibody light chain, H34, could enzymatically degrade the PD-1 molecule. In addition, it inhibited the binding of PD-1 with PD-L1.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D0CB00155D

Reference45 articles.

1. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

2. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

3. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

4. Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

5. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

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