Controlled assembly of heterotypic cells in a core–shell scaffold: organ in a droplet

Abstract

Organ in a drop: we use droplet-based microfluidics to fabricate large-scale, monodisperse, portable micro organs, each in an individual drop. We spatially assemble hepatocytes and fibroblasts in a biocompatible core–shell scaffold, forming an artificial liver in each drop, and expressing enhanced liver-specific functions.