Drug delivery nanoparticles for preventing implant bacterial infections based on the bacteria and immunity mechanisms

Author:

Chen Chen1,Xiao Qi1,Xiao Leyi1,Feng Mengge1,Liu Fangzhe1,Yao Ke1,Cui Yu1,Zhang Tiange1,Zhang Yufeng123ORCID

Affiliation:

1. State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan University, Wuhan 430079, China

2. Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China

3. TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China

Abstract

Diagram of ICG+RSG effects: ICG+RSG was irradiated by 808 nm laser to release ROS and elevate the temperature for bacterial killing. ICG+RSG promoted M2 polarization and enhance macrophage phagocytosis to improve the anti-inflammatory responses.

Funder

National Basic Research Program of China

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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