Enzymatic synthesis of amlodipine amides and evaluation of their anti-<i>Trypanosoma cruzi</i>activity-Reference-Cited by-同舟云学术

Enzymatic synthesis of amlodipine amides and evaluation of their anti-Trypanosoma cruziactivity

Published:2023 Issue:7 Volume:21 Page:1411-1421
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Elso Orlando G.¹,Bivona Augusto E.²³,Cenizo Rocío²³,Malchiodi Emilio L.²³,García Liñares Guadalupe¹^ORCID

Affiliation:

1. Laboratorio de Biocatálisis. Departamento de Química Orgánica y UMYMFOR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires-CONICET, Ciudad Universitaria, Pabellón 2, piso 3, C1428EGA Buenos Aires, Argentina

2. Instituto de Microbiología y Parasitología Médica (IMPaM), Universidad de Buenos Aires-CONICET, Paraguay 2155, piso 13, Buenos Aires, Argentina

3. Instituto de Estudios de la Inmunidad Humoral (IDEHU), Universidad de Buenos Aires-CONICET, Junín 1113, piso 4, Buenos Aires, Argentina

Abstract

An efficient lipase-catalyzed method for the amidation of amlodipine with aliphatic and phenylacetic acids in mild reaction conditions is described. Some compounds showed significant activity and selectivity againstTrypanosoma cruziamastigotes.

Funder

Universidad de Buenos Aires

Consejo Nacional de Investigaciones Científicas y Técnicas

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02271K

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