Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery
Author:
Affiliation:
1. Department of Chemistry
2. McGill University
3. Montréal
4. Canada
5. Department of Chemical and Petroleum Engineering
6. Department of Pharmacology and Therapeutics
7. Sharif University of Technology
8. Tehran
9. Iran
Abstract
Chitosan is functionalized with oxidative stress-sensitive thioketal entities in a one-pot methodology, and self-assembled into drugs or protein loaded dual stimuli responsive nanoparticles, which kill glioblastoma cells and increase nerve outgrowth.
Funder
Natural Sciences and Engineering Research Council of Canada
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2020/TB/D0TB00772B
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