Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C

Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C–H methylation

Published:2021 Issue:48 Volume:57 Page:5905-5908
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Gong Pei-Xue¹²³⁴,Xu Fangning¹²³⁴,Cheng Lu¹²³⁴,Gong Xu¹²³⁴,Zhang Jie¹²³⁴,Gu Wei-Jin¹²³⁴,Han Wei¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry and Materials Science

2. Nanjing Normal University

3. Nanjing 210023

4. China

5. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials

Abstract

The iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C–H methylation for preparing diversified methyl ketones is developed and can be applied to the late-stage modification of complex small molecules.

Funder

Priority Academic Program Development of Jiangsu Higher Education Institutions

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

China Scholarship Council

Jiangsu Provincial Department of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC01536B

Reference64 articles.

1. A charge-suppressing strategy for probing protein methylation

2. DNAzyme based visual detection of DNA methylation

3. Methyl-containing pharmaceuticals: Methylation in drug design

4. Trimethylphosphate as a Methylating Agent for Cross Coupling: A Slow-Release Mechanism for the Methylation of Arylboronic Esters

5. A sequence environment modulates the impact of methylation on the torsional rigidity of DNA

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cobalt‐Catalyzed Multi‐Substituted Alkene Synthesis from 1,3‐Dithiolanes and Grignard Reagents;Asian Journal of Organic Chemistry;2023-08-10

2. TfOH-catalyzed direct Michael addition and cascade cyclization reactions of unactivated ketones: A divergent route to functionalized benzofurans and benzofuro[3,2-b]pyridines;Tetrahedron;2023-05

3. New Paradigms in Catalysis Inspired by Cytochromes P450;Synlett;2023-02-27

4. Chemoselective Decarboxylative Protonation Enabled by Cooperative Earth‐Abundant Element Catalysis;Angewandte Chemie;2022-12-08

5. Chemoselective Decarboxylative Protonation Enabled by Cooperative Earth‐Abundant Element Catalysis;Angewandte Chemie International Edition;2022-12-08