Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma-Reference-Cited by-同舟云学术

Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma

Published:2022 Issue:1 Volume:18 Page:19-30
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Zaal Esther A.¹²^ORCID,de Grooth Harm-Jan³^ORCID,Oudaert Inge⁴^ORCID,Langerhorst Pieter¹,Levantovsky Sophie²,van Slobbe Gijs J. J.²,Jansen Jeroen W. A.²,Menu Eline⁴^ORCID,Wu Wei¹⁵^ORCID,Berkers Celia R.¹²^ORCID

Affiliation:

1. Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

2. Division of Cell Biology, Metabolism & Cancer, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

3. Department of Intensive Care & Department of Anesthesiology, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands

4. Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium

5. Netherlands Proteomics Centre, Utrecht, The Netherlands

Abstract

This study links CoQ synthesis to bortezomib resistance in multiple myeloma and provides a novel avenue for improving BTZ response through statin-induced inhibition of mitochondrial metabolism.

Funder

Fonds Wetenschappelijk Onderzoek

Kom Op Tegen Kanker

International Myeloma Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MO/D1MO00106J

Reference52 articles.

1. Multiple myeloma