Tale of the Breslow intermediate, a central player in N-heterocyclic carbene organocatalysis: then and now-Reference-Cited by-同舟云学术

Tale of the Breslow intermediate, a central player in N-heterocyclic carbene organocatalysis: then and now

Published:2021 Issue:23 Volume:12 Page:7973-7992
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Pareek Monika¹²³⁴,Reddi Yernaidu¹²³⁴^ORCID,Sunoj Raghavan B.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Indian Institute of Technology Bombay

3. Mumbai 400076

4. India

Abstract

Molecular insights on the formation, detection, and even isolation of the Breslow intermediate, which is the most important species in N-heterocyclic carbene (NHC) catalysis, as obtained from experimental and computational studies, are presented.

Funder

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01910D

Reference112 articles.

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2. Enantioselective (3+2) cycloaddition via N-heterocyclic carbene-catalyzed addition of homoenolates to cyclic N-sulfonyl trifluoromethylated ketimines: synthesis of fused N-heterocycle γ-lactams

3. NHC-Catalyzed Generation of α,β-Unsaturated Acylazoliums for the Enantioselective Synthesis of Heterocycles and Carbocycles

4. Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

5. A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

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