Design, synthesis, molecular docking and molecular dynamic studies of novel benzimidazole–thiazole derivatives as potent and selective COX-2 inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, molecular docking and molecular dynamic studies of novel benzimidazole–thiazole derivatives as potent and selective COX-2 inhibitors

Published:2023 Issue:47 Volume:47 Page:21620-21632
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Irmak Nurdan Ebru¹²^ORCID,Saglık Begum Nurpelin³^ORCID,Celik Ismail⁴^ORCID,Tahsin Sen Hasan⁵,Ozkay Yusuf³^ORCID,Ayhan-Kılcıgil Gülgün¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06560, Ankara, Turkey

2. Institute of Health Sciences, Department of Pharmaceutical Chemistry, Ankara University, 06110, Ankara, Turkey

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26210, Eskisehir, Turkey

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, 38039, Kayseri, Turkey

5. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Lokman Hekim University, 06510, Ankara, Turkey

Abstract

New benzimidazole–thiazole compounds were synthesized to selectively inhibit COX-2.

Funder

Ankara Universitesi

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ04438F

Reference61 articles.

1. Benzimidazole: An emerging scaffold for analgesic and anti-inflammatory agents

2. Recent advancements in the development of heterocyclic anti-inflammatory agents

3. Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway

4. Regulation of inflammation in cancer by eicosanoids