<i>Ce</i>Lab, a microfluidic platform for the study of life history traits, reveals metformin and SGK-1 regulation of longevity and reproductive span-Reference-Cited by-同舟云学术

CeLab, a microfluidic platform for the study of life history traits, reveals metformin and SGK-1 regulation of longevity and reproductive span

Published:2023 Issue:12 Volume:23 Page:2738-2757
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Sohrabi Salman¹²³,Cota Vanessa¹²,Murphy Coleen T.¹²^ORCID

Affiliation:

1. Department of Molecular Biology &, LSI Genomics, Princeton University, Princeton, NJ 08544, USA

2. LSI Genomics, Princeton University, Princeton, NJ 08544, USA

3. Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76010, USA

Abstract

CeLab enables high-throughput C. elegans lifespans, reproductive spans, progeny count assays and body size measurements. Adult treatment of metformin at low dose increases RS, and the nutrient-sensing mTOR pathway mutant sgk-1 reproduces until death.

Funder

Glenn Foundation for Medical Research

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D3LC00028A

Reference71 articles.

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4. Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

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