Repurposing of antidepression drug sertraline for antimicrobial activity against Staphylococcus aureus: a potential approach for the treatment of osteomyelitis

Author:

Muthu D.1234ORCID,Gowri M.1234ORCID,Suresh Kumar G.1564ORCID,Kattimani V. S.7894ORCID,Girija E. K.1234ORCID

Affiliation:

1. Department of Physics

2. Periyar University

3. Salem 636 011

4. India

5. K.S. Rangasamy College of Arts and Science (Autonomous)

6. Tiruchengode 637 215

7. Department of Oral and Maxillofacial Surgery

8. Sibar Institute of Dental Sciences

9. Guntur 522 509

Abstract

We report a potential approach to synthesize the repurposed sertraline drug-loaded hydroxyapatite nanoparticles using eggshell as the calcium source via the in situ precipitation method for the treatment of osteomyelitis.

Funder

Department of Science and Technology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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