Prolonged bioluminescence imaging in living cells and mice using novel pro-substrates forRenillaluciferase

Author:

Yuan Mingliang12345,Ma Xiaojie6758,Jiang Tianyu12345,Gao Yuqi12345,Cui Yuanyuan12345,Zhang Chaochao12345,Yang Xingye12345,Huang Yun910111213,Du Lupei12345,Yampolsky Ilia1415161715,Li Minyong12345ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. Key Laboratory of Chemical Biology (MOE)

3. School of Pharmacy

4. Shandong University

5. Jinan

6. Department of Otorhinolaryngology

7. Qilu Hospital of Shandong University

8. China

9. Centre for Epigenetics and Disease Prevention

10. Institute of Biosciences and Technology

11. Department of Molecular and Cellular Medicine

12. College of Medicine

13. Texas A&M University

14. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

15. Moscow 117997

16. Russia

17. Pirogov Russian National Research Medical University

Abstract

The prodrug or caged-luciferin strategy affords an excellent platform for persistent bioluminescence imaging.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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