Introducing nitrogen atoms to amidoalkylindoles: potent and selective cannabinoid type 2 receptor agonists with improved aqueous solubility-Reference-Cited by-同舟云学术

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Introducing nitrogen atoms to amidoalkylindoles: potent and selective cannabinoid type 2 receptor agonists with improved aqueous solubility

Published:2019 Issue:12 Volume:10 Page:2131-2139
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Ji Yue-Yang¹²³⁴⁵,Wang Zhi-Long⁶⁷⁸⁹¹⁰,Pei Fang-Ning¹²³⁴⁵,Shi Jun-Jie¹²³⁴⁵,Li Jiao-Jiao¹²³⁴⁵,Gunosewoyo Hendra¹¹¹²¹³¹⁴¹⁵^ORCID,Yang Fan¹²³⁴⁵^ORCID,Tang Jie¹⁶²³⁴⁵,Xie Xin⁶⁷⁸⁹¹⁰,Yu Li-Fang¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development

2. School of Chemistry and Molecular Engineering

3. East China Normal University

4. Shanghai 200062

5. China

6. CAS Key Laboratory of Receptor Research

7. National Center for Drug Screening

8. Shanghai Institute of Materia Medica

9. Chinese Academy of Sciences

10. Shanghai 201203

11. School of Pharmacy and Biomedical Sciences

12. Faculty of Health Sciences

13. Curtin University

14. Perth

15. Australia

16. Shanghai Key Laboratory of Green Chemistry and Chemical Process

Abstract

Previously we identified a series of amidoalkylindoles as potent and selective CB₂ partial agonists.

Funder

National Natural Science Foundation of China

Shanghai Municipal Education Commission

State Key Laboratory of Drug Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00411D

Reference33 articles.

1. Structure of a cannabinoid receptor and functional expression of the cloned cDNA

2. Molecular characterization of a peripheral receptor for cannabinoids

3. Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future

4. Endocannabinoid Signaling in the Brain

5. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials

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