Tripodal molecular propellers perturb microtubule dynamics: indole acts as a blade and plays a crucial role in anticancer activity-Reference-Cited by-同舟云学术

Tripodal molecular propellers perturb microtubule dynamics: indole acts as a blade and plays a crucial role in anticancer activity

Published:2019 Issue:16 Volume:55 Page:2356-2359
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Barman Surajit¹²³,Das Gaurav¹²³⁴⁵^ORCID,Mondal Prasenjit¹²³⁴⁵^ORCID,Pradhan Krishnangsu¹²³,Jana Batakrishna⁶⁷⁸,Bhunia Debmalya¹²³,Saha Abhijit¹²³,Kar Chirantan¹²³,Ghosh Surajit¹²³⁴⁵^ORCID

Affiliation:

1. Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology

2. Kolkata

3. India

4. Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus

5. Kolkata 700 032

6. Department of Chemistry, UNIST

7. Ulsan 44919

8. Republic of Korea

Abstract

A microtubule targeted tripodal molecular propeller has been constructed having indoles as appendages. It strongly interacts at the DCVJ site of tubulin and controls the dynamicity of microtubule.

Funder

Department of Biotechnology, Ministry of Science and Technology

Indian Council of Medical Research

Science and Engineering Research Board

University Grants Commission

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC00074G

Reference23 articles.

1. MICROTUBULE POLYMERIZATION DYNAMICS

2. Structural Insights into Microtubule Function

3. Microtubule dynamic instability

4. Beyond self-assembly: From microtubules to morphogenesis

5. Microtubules as a target for anticancer drugs

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