Synthesis of an amphiphilic graft copolymer bearing a hydrophilic poly(acrylate acid) backbone for drug delivery of methotrexate-Reference-Cited by-同舟云学术

Synthesis of an amphiphilic graft copolymer bearing a hydrophilic poly(acrylate acid) backbone for drug delivery of methotrexate

Published:2017 Issue:86 Volume:7 Page:54562-54569
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Wei¹²³⁴⁵,Zhou Xin¹²³⁴⁵,Wei Min¹²³⁴⁵,Liu Zude¹²³⁴⁵,Lu Guolin⁶⁷⁸⁹¹⁰,Huang Xiaoyu⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Department of Orthopaedic Surgery

2. Renji Hospital

3. School of Medicine

4. Shanghai Jiaotong University

5. Shanghai 200127

6. Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules

7. Shanghai Institute of Organic Chemistry

8. Chinese Academy of Sciences

9. Shanghai 200032

10. People's Republic of China

Abstract

This article reports the synthesis of a PAA-g-PLA amphiphilic graft polymer, which could self-assemble into large compound micelles in aqueous media for sustained release of MTX.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA11975E

Reference64 articles.

1. Biodegradable polymers as biomaterials

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5. Compaction and Transmembrane Delivery of pDNA: Differences between l-PEI and Two Types of Amphiphilic Block Copolymers

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