Methylene-linked bis-phenylbenzimidazoles – a new scaffold to target telomeric DNA/RNA hybrid duplex-Reference-Cited by-同舟云学术

Methylene-linked bis-phenylbenzimidazoles – a new scaffold to target telomeric DNA/RNA hybrid duplex

Published:2018 Issue:24 Volume:16 Page:4424-4428
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Islam M. K.¹²³⁴⁵^ORCID,Jackson P. J. M.¹²³⁴⁵,Thurston D. E.¹²³⁴⁵^ORCID,Rahman K. M.¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Pharmaceutical Science

2. School of Cancer and Pharmaceutical Sciences

3. King's College London

4. London SE1 9NH

5. UK

Abstract

A series of methylene-linked bis-phenylbenzimidazoles are reported that stabilize telomeric DNA/RNA hybrid structures while having negligible affinity for DNA/DNA duplexes.

Funder

Commonwealth Scholarship Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02709E

Reference19 articles.

1. Recognition of the unique structure of DNA:RNA hybrids

2. The formation of hybrid DNA molecules and their use in studies of DNA homologies

3. A HYBRID HELIX CONTAINING BOTH DEOXYRIBOSE AND RIBOSE POLYNUCLEOTIDES AND ITS RELATION TO THE TRANSFER OF INFORMATION BETWEEN THE NUCLEIC ACIDS

4. The structure of a DNA-RNA hybrid.

5. Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro

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