An asymmetric three-component reaction of a diazo compound with an alcohol and a seven-membered imine-Reference-Cited by-同舟云学术

An asymmetric three-component reaction of a diazo compound with an alcohol and a seven-membered imine

Published:2022 Issue:8 Volume:9 Page:2102-2108
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xie Xiongda¹,Bao Ming¹,Chen Kewei¹,Xu Xinfang¹^ORCID,Hu Wenhao¹

Affiliation:

1. Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

Abstract

An asymmetric three-component reaction via Mannich-type interception of an oxonium ylide with a 7-membered imine has been disclosed, providing chiral dibenzoazepine analogues with excellent stereoselectivity and structural diversity.

Funder

National Postdoctoral Program for Innovative Talents

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00076H

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