Senescence-associated sialidase revealed by an activatable fluorescence-on labeling probe-Reference-Cited by-同舟云学术

Senescence-associated sialidase revealed by an activatable fluorescence-on labeling probe

Published:2018 Issue:82 Volume:54 Page:11566-11569
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhu Rui¹²³⁴⁵,Wang Siyu¹²³⁴⁵,Xue Zhongwei¹²³⁴⁵,Han Jiahuai⁶⁷⁸⁹¹⁰,Han Shoufa¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory for Physical Chemistry of Solid Surfaces

2. Department of Chemical Biology

3. College of Chemistry and Chemical Engineering

4. The Key Laboratory for Chemical Biology of Fujian Province

5. The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation

6. State Key Laboratory of Cellular Stress Biology

7. Innovation Center for Cell Signalling Network

8. School of Life Sciences

9. Xiamen University

10. Xiamen

Abstract

A fluorescence-quenched substrate of sialidase enables fluorescence-on live cell imaging of sialidases, revealing up-regulation of lysosome-associated sialidase in cell senescence.

Funder

National Natural Science Foundation of China

Xiamen University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC07024E

Reference56 articles.

1. Senescence in Health and Disease

2. Manipulating senescence in health and disease: emerging tools

3. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

4. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

5. A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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