RNA-based boronate internucleosidic linkages: an entry into reversible templated ligation and loop formation

Author:

Gimenez Molina Alejandro12345ORCID,Barvik Ivan678910,Müller Sabine11121314ORCID,Vasseur Jean-Jacques12345ORCID,Smietana Michael12345ORCID

Affiliation:

1. Institut des Biomolecules Max Mousseron

2. IBMM UMR 5247 CNRS

3. Université de Montpellier

4. ENSCM

5. 34095 Montpellier

6. Institute of Physics

7. Faculty of Mathematics and Physics

8. Charles University

9. 121 16 Prague 2

10. Czech Republic

11. Institut für Biochemie

12. Ernst-Moritz-Arndt-Universität Greifswald

13. D-17489 Greifswald

14. Germany

Abstract

The synthesis of a 5′-boronoribonucleotidic phosphoramidite building block has been achieved and incorporated at the 5′ extremities of RNA sequences for the templated assembly of RNA shortmers.

Funder

FP7 People: Marie-Curie Actions

Agence Nationale de la Recherche

Deutsche Forschungsgemeinschaft

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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