A metal-free synthesis of pyrimidines from amidines with α,β-unsaturated ketones<i>via</i>tandem [3 + 3] annulation and visible-light-enabled photo-oxidation-Reference-Cited by-同舟云学术

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A metal-free synthesis of pyrimidines from amidines with α,β-unsaturated ketonesviatandem [3 + 3] annulation and visible-light-enabled photo-oxidation

Published:2023 Issue:16 Volume:21 Page:3411-3416
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Jinshan¹,Zhuo Jiatian¹,Tan Qi¹,Zhou Min¹,Ma Lin¹,Zhang Min¹²^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, China

2. Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development, Guangxi University, Nanning, Guangxi 530004, China

Abstract

A facile synthesis of pyrimidines from amidines and α,β-unsaturated ketones, involving a [3 + 3] annulation followed by visible light photo-oxidation using air as terminal oxidant, is reported.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02298B

Reference59 articles.

1. Pyrimidine as Constituent of Natural Biologically Active Compounds

2. 1,2,4-Triazolo[1,5-a]pyrimidines in drug design

3. Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

4. Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors

5. Thiazolo[4,5-d]pyrimidines as a privileged scaffold in drug discovery

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