Pillar[6]MaxQ functions as an <i>in vivo</i> sequestrant for rocuronium and vecuronium-Reference-Cited by-同舟云学术

Pillar[6]MaxQ functions as an in vivo sequestrant for rocuronium and vecuronium

Published:2024 Issue:32 Volume:60 Page:4350-4353
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhang Wanping¹,Bazan-Bergamino Emmanuel A.²,Doan Anton P.²,Zhang Xiangjun¹,Isaacs Lyle²^ORCID

Affiliation:

1. College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. China

2. Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA

Abstract

P6MQ binds tightly (Ka > 1011 M−1) to rocuronium and vecuronium in vitro (PBS) and functions as an in vivo reversal agent for these neuromuscular blocking agents.

Funder

Chongqing Medical University

College of Computer, Mathematical, and Natural Sciences, University of Maryland

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC00772G

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5. A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).