Rapid quantification of a chemically synthesized peptide GAP162 in rat plasma by liquid chromatography/triple quadrupole tandem mass spectrometry and application to a pharmacokinetic study-Reference-Cited by-同舟云学术

Rapid quantification of a chemically synthesized peptide GAP162 in rat plasma by liquid chromatography/triple quadrupole tandem mass spectrometry and application to a pharmacokinetic study

Published:2015 Issue:64 Volume:5 Page:51708-51716
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhao Xiaoping¹²³⁴,Kang Liping⁵⁶⁷³⁴,Zhang Taichang⁸⁹¹⁰⁴,Chen Jianhua¹¹¹²⁴,Ren Xinyi¹²³⁴,Bao Yuanwu⁸⁹¹⁰⁴,Cheng Yuanguo¹²³⁴

Affiliation:

1. State Key Laboratory of Pathogen and Biosecurity

2. Beijing Institute of Microbiology and Epidemiology

3. Beijing

4. China

5. State Key Laboratory Breeding Base of Dao-di Herbs

6. National Resource Center of Chinese Materia Medica

7. China Academy of Chinese Medical Sciences

8. DMPK Department

9. BioDuro (Shanghai) Inc.

10. Shanghai

11. Jianghan University

12. Wuhan

Abstract

Liquid chromatography/tandem mass spectrometry (LC-MS/MS) is a promising analytical platform for the quantification of therapeutic peptide in biological fluids for pharmacokinetics (PK) studies.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA05188F

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