Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system-Reference-Cited by-同舟云学术

Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system

Published:2019 Issue:1 Volume:17 Page:30-34
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kasim Johanes K.¹²³⁴^ORCID,Kavianinia Iman¹²³⁴⁵^ORCID,Ng Jin¹²³⁴⁶,Harris Paul W. R.¹²³⁴⁵^ORCID,Birch Nigel P.¹²³⁴⁶,Brimble Margaret A.¹²³⁴⁵^ORCID

Affiliation:

1. School of Biological Sciences

2. The University of Auckland

3. Auckland 1010

4. New Zealand

5. Maurice Wilkins Centre for Molecular Biodiscovery

6. Brain Research New Zealand Rangahau Roro Aotearoa and Centre for Brain Research

Abstract

The amyloidogenic Aβ₄₂ peptide was prepared in high purity and yield enabling biophysical characterisation studies using a double linker system and the incorporation of pseudoprolines.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02929F

Reference28 articles.

1. Epidemiology of Alzheimer disease

2. Emerging Concepts in Alzheimer's Disease

3. Alzheimer's Disease: The Amyloid Cascade Hypothesis

4. Amyloid Precursor Protein Trafficking, Processing, and Function

5. Aβ42 is More Rigid than Aβ40 at the C Terminus: Implications for Aβ Aggregation and Toxicity

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