A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging-Reference-Cited by-同舟云学术

A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging

Published:2015 Issue:37 Volume:13 Page:9559-9563
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fletcher Sally A.¹²³⁴,Sin Pak Kwan Brian⁵²³⁴,Nobles Muriel⁶⁷³⁴,Årstad Erik¹²³⁴⁵,Tinker Andrew⁶⁷³⁴,Baker James R.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University College London

3. London

4. UK

5. Division of Medicine

6. Barts and The London

7. Queen Mary's School of Medicine and Dentistry

Abstract

We report a concise approach to a multimodal imaging reagent for peptide labelling via disulfide bridging. The reagent is constructed using a one pot, three component, [3 + 2] cycloaddition of a fluorescent azide with a dithiomaleimide-alkyne, with concomitant incorporation of ¹²⁵I.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01468A

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