Sesamin inhibits hypoxia-stimulated angiogenesis <i>via</i> the NF-κB p65/HIF-1α/VEGFA signaling pathway in human colorectal cancer-Reference-Cited by-同舟云学术

Sesamin inhibits hypoxia-stimulated angiogenesis via the NF-κB p65/HIF-1α/VEGFA signaling pathway in human colorectal cancer

Published:2022 Issue:17 Volume:13 Page:8989-8997
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Huang Yefei¹²³,Liu Zixuan¹²³,Li Lingling¹²³,Jiang Min¹²³,Tang Yu¹²³,Zhou Li¹²³,Li Jing¹²³,Chen Yansu¹²³^ORCID

Affiliation:

1. School of Public Health, Xuzhou Medical University, Xuzhou 221004, China

2. Key Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou 221004, China

3. Key Lab of Environment and Health, Xuzhou Medical University, Xuzhou 221004, China

Abstract

This study suggests that sesamin can restrain NF-κB p65 to activate HIF-1α transcription under hypoxic conditions, thereby inhibiting VEGFA expression and effectively suppressing colorectal tumor angiogenesis.

Funder

Xuzhou Medical University

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00345G

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