Cu(i) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action
Author:
Affiliation:
1. UCIBIO
2. Departamento de Ciências da Vida
3. Faculdade de Ciências e Tecnologia
4. Universidade Nova de Lisboa
5. Portugal
6. DQB-FCUL
7. Departamento de Química e Bioquímica
8. Faculdade de Ciências
9. Universidade de Lisboa
Abstract
Cu(i) antiproliferative and cytostatic effect in ovarian cancer cells. Induction of reactive oxygen species which cause DNA damage and changes in protein folding triggering apoptotic and autophagic cell death.
Funder
Ministério da Ciência, Tecnologia e Ensino Superior
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/DT/D0DT03566A
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