Fluorescently labelled thioacetazone for detecting the interaction with <i>Mycobacterium</i> dehydratases HadAB and HadBC-Reference-Cited by-同舟云学术

Fluorescently labelled thioacetazone for detecting the interaction with Mycobacterium dehydratases HadAB and HadBC

Published:2022 Issue:7 Volume:20 Page:1444-1452
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Singh Bina K.¹,Singha Monisha²,Basak Shyam²^ORCID,Biswas Rupam³,Das Amit K.¹³,Basak Amit¹²^ORCID

Affiliation:

1. School of Bioscience, Indian Institute of Technology, Kharagpur, 721302, India

2. Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302, India

3. Department of Biotechnology, Indian Institute of Technology, Kharagpur, 721302, India

Abstract

Photo-cross-linking experiments demonstrated direct interactions of the drug thioacetazone with its target enzymes, namely both the dehydratases HadAB and HadBC via the monooxygenase EthA in Mycobacterium tuberculosis.

Funder

Department of Biotechnology, Ministry of Science and Technology

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02080C

Reference37 articles.

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2. Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

3. The Envelope Layers of Mycobacteria with Reference to their Pathogenicity

4. A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response

5. Pleiotropic consequences of gene knockouts in the phthiocerol dimycocerosate and phenolic glycolipid biosynthetic gene cluster of the opportunistic human pathogenMycobacterium marinum

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