Genetically engineered haemoglobin wrapped covalently with human serum albumins as an artificial O2 carrier-Reference-Cited by-同舟云学术

Genetically engineered haemoglobin wrapped covalently with human serum albumins as an artificial O2 carrier

Published:2020 Issue:6 Volume:8 Page:1139-1145
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Funaki Ryosuke¹²³⁴⁵,Okamoto Wataru¹²³⁴⁵,Endo Chihiro¹²³⁴⁵,Morita Yoshitsugu¹²³⁴⁵^ORCID,Kihira Kiyohito⁶⁷⁸⁹⁵^ORCID,Komatsu Teruyuki¹²³⁴⁵^ORCID

Affiliation:

1. Department of Applied Chemistry

2. Faculty of Science and Engineering

3. Chuo University

4. Tokyo 112-8551

5. Japan

6. JEM Utilization Center

7. Human Spaceflight Technology Directorate

8. Japan Aerospace Exploration Agency (JAXA)

9. Ibaraki 305-8505

Abstract

Recombinant human haemoglobin expressed in Pichia yeast was wrapped covalently with recombinant human serum albumins, yielding a core–shell structured rHbA(X)–rHSA₃ cluster as an entirely synthetic O₂ carrier used for a red blood cell substitute.

Funder

Japan Society for the Promotion of Science

Chuo University

Naito Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2020/TB/C9TB02184A

Reference43 articles.

1. Structure of Hæmoglobin: A Three-Dimensional Fourier Synthesis at 5.5-Å. Resolution, Obtained by X-Ray Analysis