A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis

Author:

Ouyang Xumei12341ORCID,Wang Xiaoling12341,Kraatz Heinz-Bernhard5678ORCID,Ahmadi Soha5678ORCID,Gao Jianqing1910114ORCID,Lv Yuanyuan1234,Sun Xiaoyi1234ORCID,Huang Yongzhuo121314154ORCID

Affiliation:

1. Department of Pharmacy

2. Zhejiang University City College

3. Hangzhou 310015

4. China

5. Department of Physical and Environmental Sciences

6. University of Toronto Scarborough

7. Toronto

8. Canada

9. School of Ophthalmology & Optometry and Eye Hospital

10. Wenzhou Medical University

11. Wenzhou

12. State Key Laboratory of Drug Research

13. Shanghai Institute of Materia Medica

14. Chinese Academy of Sciences

15. Shanghai

Abstract

A cell-based biomimetic delivery system characterized by its “Trojan horse” property is developed, in which the PDA-Ce6 nanoparticles were loaded in the MSCs for tumor-targeted delivery and combination PDT/PTT for retarding lung melanoma metastasis.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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