Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming-Reference-Cited by-同舟云学术

Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming

Published:2023 Issue:9 Volume:40 Page:1498-1520
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Wang Jialiang¹^ORCID,Deng Zixin¹,Liang Jingdan¹^ORCID,Wang Zhijun¹^ORCID

Affiliation:

1. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, China

Abstract

This article provides a comprehensive overview of the structural enzymology of type I iPKSs, focusing on the individual domain structures, catalytic mechanisms and the representative programming activities that each domain contributes.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NP/D3NP00015J

Reference102 articles.

1. Genetic Contributions to Understanding Polyketide Synthases