Modified aryldifluorophenylsilicates with improved activity and selectivity in nucleophilic fluorination of secondary substrates-Reference-Cited by-同舟云学术

Modified aryldifluorophenylsilicates with improved activity and selectivity in nucleophilic fluorination of secondary substrates

Published:2024 Issue:31 Volume:14 Page:22326-22334
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Trojan Michal¹^ORCID,Hroch Adam¹^ORCID,Gruden Evelin²^ORCID,Cvačka Josef³^ORCID,Čejka Jan⁴^ORCID,Tavčar Gašper²^ORCID,Rybáčková Markéta¹^ORCID,Kvíčala Jaroslav¹^ORCID

Affiliation:

1. Department of Organic Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic

2. Department of Inorganic Chemistry and Technology, “Jožef Stefan” Institute, Jamova Cesta 39, Ljubljana, Slovenia

3. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo Náměstí 542/2, 160 00 Prague 6, Czech Republic

4. Department of Solid State Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic

Abstract

Difluorosilicates with MeO group(s) gave improved nucleophilic fluorination activity and selectivity of secondary substrates, while the CF3 group gave inferior results.

Funder

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA04332D

Reference40 articles.

1. Contribution of Organofluorine Compounds to Pharmaceuticals

2. Fluorine-containing drugs approved by the FDA in 2021

3. Where Does the Fluorine Come From? A Review on the Challenges Associated with the Synthesis of Organofluorine Compounds

4. Current Contributions of Organofluorine Compounds to the Agrochemical Industry

5. Organofluorine chemistry: applications, sources and sustainability