Identification of key residues in Debaryomyces hansenii carbonyl reductase for highly productive preparation of (S)-aryl halohydrins-Reference-Cited by-同舟云学术

Identification of key residues in Debaryomyces hansenii carbonyl reductase for highly productive preparation of (S)-aryl halohydrins

Published:2015 Issue:86 Volume:51 Page:15728-15731
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Xu Guo-Chao¹²³⁴⁵,Shang Yue-Peng¹²³⁴,Yu Hui-Lei¹²³⁴,Xu Jian-He¹²³⁴

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, and Shanghai Collaborative Innovation Center

2. East China University of Science and Technology, for Biomanufacturing

3. Shanghai 200237

4. People's Republic of China

5. The Key Laboratory of Industrial Biotechnology

Abstract

Key residues were identified through combinatorial mutation of conserved residues with notably improved productivity in asymmetric reduction of α-chloroacetophenone.

Funder

Huo Yingdong Education Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC06796K

Reference24 articles.

1. Asymmetric dihydroxylation route to (R)-isoprenaline, (R)-norfluoxetine and (R)-fluoxetine

2. Enantioconvergent production of (R)-1-phenyl-1,2-ethanediol from styrene oxide by combining theSolanum tuberosum and an evolvedAgrobacterium radiobacter AD1 epoxide hydrolases

3. A novel generation of optically active 1,2-diols from the racemates by using halohydrin dehydro-dehalogenase

4. Stereo-Complementary Two-Step Cascades Using a Two-Enzyme System Leading to Enantiopure Epoxides

5. Steric vs. electronic effects in the Lactobacillus brevis ADH-catalyzed bioreduction of ketones

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