<i>De novo</i> synthesis of inherently chiral heteracalix[4]aromatics from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular S<sub>N</sub>Ar reaction-Reference-Cited by-同舟云学术

De novo synthesis of inherently chiral heteracalix[4]aromatics from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular S_NAr reaction

Published:2024 Issue:10 Volume:15 Page:3610-3615
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Li Xing-Chi¹,Cheng Ying¹^ORCID,Wang Xu-Dong²,Tong Shuo³^ORCID,Wang Mei-Xiang³^ORCID

Affiliation:

1. College of Chemistry, Beijing Normal University, Beijing 100875, China

2. Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

3. MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China

Abstract

N3,O-calix[2]arene[2]triazines, whose inherent chirality arises from one different heteroatom linkage, were synthesized enantioselectively in ee up to 95% from macrocyclization via chiral monophosphoric acid-catalyzed intramolecular SNAr reaction.

Funder

National Natural Science Foundation of China

Tsinghua University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC06436K

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