Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate via aza-Michael–Michael addition-Reference-Cited by-同舟云学术

Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate via aza-Michael–Michael addition

Published:2020 Issue:23 Volume:10 Page:13591-13600
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Palanimuthu Arunan¹²³⁴^ORCID,Chen Chinpiao⁵⁶⁷⁴¹^ORCID,Lee Gene-Hsian⁸⁹¹⁰¹¹⁴

Affiliation:

1. Department of Chemistry

2. National Dong Hwa University

3. Hualien 974

4. Taiwan

5. Department of Nursing

6. Tzu Chi University of Science and Technology

7. Hualien 970

8. Instrumentation Center

9. College of Science

10. National Taiwan University

11. Taipei 106

Abstract

A three-component cascade reaction involving 2-alkenyl aniline, aldehydes, and ethyl cyanoacetate in the presence of DBU to synthesize highly substituted 1,2,3,4-tetrahydroquinolines is reported.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA01264E

Reference37 articles.

1. Cascade Reactions in Total Synthesis

2. Martinelline and Martinellic Acid, Novel G-Protein Linked Receptor Antagonists from the Tropical Plant Martinella iquitosensis (Bignoniaceae)

3. Alkaloids fromGalipea officinalis

4. Antiplasmodial and Cytotoxic Activity of Galipinine and other Tetrahydroquinolines from Galipea officinalis

5. Enantioselective Syntheses of Tetrahydroquinolines Based on Iridium-Catalyzed Allylic Substitutions: Total Syntheses of (+)-Angustureine and (-)-Cuspareine

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