Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation-Reference-Cited by-同舟云学术

Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation

Published:2018 Issue:34 Volume:16 Page:6306-6315
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xin Bo-Tao¹²³⁴,van Tol Bianca D. M.¹²³⁴^ORCID,Ovaa Huib¹²³⁴,Geurink Paul P.¹²³⁴^ORCID

Affiliation:

1. Oncode Institute and Department of Cell and Chemical Biology

2. Leiden University Medical Center

3. 2333 ZC Leiden

4. The Netherlands

Abstract

γ-Thionorleucine is synthesized and used for N-terminal chemical protein modification by native chemical ligation–desulfurization to prepare linear diubiquitin.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01627E

Reference40 articles.

1. Synthesis of Proteins by Native Chemical Ligation

2. Synthesis of Peptides and Proteins without Cysteine Residues by Native Chemical Ligation Combined with Desulfurization

3. Free-Radical-Based, Specific Desulfurization of Cysteine: A Powerful Advance in the Synthesis of Polypeptides and Glycopolypeptides

4. Native Chemical Ligation at Phenylalanine

5. Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis

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