Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids-Reference-Cited by-同舟云学术

Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids

Published:2021 Issue:17 Volume:19 Page:3763-3775
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Rodriguez Sandra¹²³⁴,Uria Uxue¹²³⁴^ORCID,Reyes Efraim¹²³⁴^ORCID,Prieto Liher¹²³⁴^ORCID,Rodríguez-Rodríguez Marta¹²³⁴,Carrillo Luisa¹²³⁴^ORCID,Vicario Jose L.¹²³⁴^ORCID

Affiliation:

1. Department of Organic and Inorganic Chemistry

2. University of the Basque Country

3. 48080 Bilbao

4. Spain

Abstract

The 8-azabicyclo[3.2.1]octane core is the central motif of tropane alkaloids. This review compiles the methodologies employed to synthesize this scaffold in an enantioenriched form from achiral starting materials.

Funder

Ministerio de Ciencia e Innovación

Ministerio de Educación, Cultura y Deporte

Eusko Jaurlaritza

Euskal Herriko Unibertsitatea

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00143D

Reference84 articles.

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2. Tropane alkaloids

3. M. Lounasmaa and T.Tamminen , in The Alkaloids: Chemistry and Pharmacology , ed. G. A. Cordell , Academic Press , London , 1993 , vol. 44 , ch. 1, pp. 1–114

4. Synthetic Approaches to Enantiomerically Pure 8-Azabicyclo[3.2.1]octane Derivatives

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