Fluorinated alcohol mediated N,N′-dialkylation of amino acid derivatives via cascade [1,5]-hydride transfer/cyclization for concise synthesis of tetrahydroquinazoline-Reference-Cited by-同舟云学术

Fluorinated alcohol mediated N,N′-dialkylation of amino acid derivatives via cascade [1,5]-hydride transfer/cyclization for concise synthesis of tetrahydroquinazoline

Published:2020 Issue:5 Volume:18 Page:895-904
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Shi Hongjin¹²³⁴,Xu Lubin¹²³⁴,Ren Didi¹²³⁴,Wang Liang¹²³⁴⁵^ORCID,Guo Weisi⁵⁶⁷⁸,Li Shuai-Shuai¹²³⁴⁵^ORCID

Affiliation:

1. College of Chemistry and Pharmaceutical Sciences

2. Qingdao Agricultural University

3. Qingdao 266109

4. China

5. Shandong Key Laboratory of Biochemical Analysis; College of Chemistry and Molecular Engineering

6. Qingdao University of Science and Technology

7. Qingdao 266042

8. P. R. China

Abstract

Structurally diverse amino acids and their ester derivatives were conveniently N,N′-dialkylated via TFE promoted cascade condensation/[1,5]-hydride transfer/cyclization for straightforward construction of tetrahydroquinazolines incorporating various amino acids.

Funder

National Natural Science Foundation of China

Key Technology Research and Development Program of Shandong

Qingdao University of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02498K

Reference42 articles.

1. Catalytic Asymmetric Synthesis of α-Amino Acids