Efficient kinetic resolution in the asymmetric transfer hydrogenation of 3-aryl-indanones: applications to a short synthesis of (+)-indatraline and a formal synthesis of (R)-tolterodine
Author:
Affiliation:
1. Korea Chemical Bank
2. Korea Research Institute of Chemical Technology
3. Daejeon 305-600
4. Korea
5. Department of Medicinal Chemistry and Pharmacology
Abstract
Efficient kinetic resolution occurs in ATH of racemic 3-arylindanones using (R,R)-or (S,S)-Ts-DENEB catalyst and HCO2H/Et3N mixture providing near equal yields of cis-3-arylindanols and unreacted 3-arylindanones with excellent stereoselectivities.
Funder
National Research Foundation of Korea
Korea Research Institute of Chemical Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA04538E
Reference56 articles.
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