Asymmetric synthesis of 3-substituted tetrahydro-2-benzazepines-Reference-Cited by-同舟云学术

Asymmetric synthesis of 3-substituted tetrahydro-2-benzazepines

Published:2015 Issue:26 Volume:13 Page:7265-7281
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Quick Matthias P.¹²³,Fröhlich Roland⁴²³,Schepmann Dirk¹²³⁵⁶,Wünsch Bernhard¹²³⁵⁶

Affiliation:

1. Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster

2. D-48149 Münster

3. Germany

4. Organisch-chemisches Institut der Westfälischen Wilhelms-Universität Münster

5. Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM)

6. Westfälische Wilhelms-Universität Münster

Abstract

Diastereoselective opening of a tricyclic oxazolidine with allyltrimethylsilane represents a key step in the synthesis of enantiomerically pure 3-substituted tetrahydro-2-benzazepines.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00731C

Reference59 articles.

1. Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity

2. Synthesis and dopaminergic binding of 2-aryldopamine analogs: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes

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4. Synthesis and structure/NMDA receptor affinity relationships of 1-substituted tetrahydro-3-benzazepines

5. Asymmetric Synthesis of 1-Substituted Tetrahydro-3-benzazepines as NMDA Receptor Antagonists

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