Succinate communicates pro-inflammatory signals to the host and regulates bile acid enterohepatic metabolism in a pig model-Reference-Cited by-同舟云学术

Succinate communicates pro-inflammatory signals to the host and regulates bile acid enterohepatic metabolism in a pig model

Published:2022 Issue:21 Volume:13 Page:11070-11082
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Xuan¹²,Ren Yuting¹²,Huang Guowen¹²,Zhang Ruofan¹²,Zhang Yanan¹²,Zhu Weiyun¹²,Yu Kaifan¹²^ORCID

Affiliation:

1. Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China

2. National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing 210095, China

Abstract

Pro-inflammatory cytokines induced by succinate blocked the activation of FXR and its target genes and disturbed bile acid enterohepatic circulation.

Funder

Jiangsu Agricultural Science and Technology Innovation Fund

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO01958B

Reference46 articles.

1. Host-Gut Microbiota Metabolic Interactions

2. Gut microbiota–generated metabolites in animal health and disease

3. Gut microbial metabolites as multi-kingdom intermediates

4. You are what you eat: diet, health and the gut microbiota

5. Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

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