Impact of the in vitro gastrointestinal passage of biopolymer-based nanoparticles on insulin absorption-Reference-Cited by-同舟云学术

Impact of the in vitro gastrointestinal passage of biopolymer-based nanoparticles on insulin absorption

Published:2016 Issue:24 Volume:6 Page:20155-20165
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lopes Marlene¹²³⁴⁵,Derenne Amelie¹²³⁴⁶,Pereira Carla⁷⁸⁹⁴,Veiga Francisco¹²³⁴⁵,Seiça Raquel¹⁰¹¹⁶³⁴,Sarmento Bruno⁷⁸⁹⁴¹²,Ribeiro António¹²³⁴⁷^ORCID

Affiliation:

1. Faculty of Pharmacy

2. University of Coimbra

3. 3000-548 Coimbra

4. Portugal

5. CNC – Center for Neuroscience and Cell Biology

6. Faculty of Medicine

7. I3S – Instituto de Investigação e Inovação em Saúde

8. University of Porto

9. 4150-180 Porto

10. Laboratory of Physiology

11. IBILI – Institute for Biomedical Imaging and Life Sciences

12. CESPU

Abstract

Behavior of insulin-loaded biopolymer-based nanoparticles upon passage through the gastrointestinal tract. Intestinal pH triggered insulin release from nanoparticles, allowing its permeability through cell-based engineered intestinal models.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA26224K

Reference67 articles.

1. Oral insulin delivery1Abbreviations: GI, gastrointestinal; IDDM, insulin-dependent diabetes mellitus; IU, international units; NIDDM, non-insulin-dependent diabetes mellitus; PIN, phase inversion nanoencapsulation; ZOT, zona occludens toxin.1

2. Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles

3. Facilitated nanoscale delivery of insulin across intestinal membrane models

4. Nanoparticulate biopolymers deliver insulin orally eliciting pharmacological response

5. Floating dosage forms to prolong gastro-retention—The characterisation of calcium alginate beads

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