EGCG oxidation-derived polymers induce apoptosis in digestive tract cancer cells <i>via</i> regulating the renin–angiotensin system-Reference-Cited by-同舟云学术

EGCG oxidation-derived polymers induce apoptosis in digestive tract cancer cells via regulating the renin–angiotensin system

Published:2024 Issue:4 Volume:15 Page:2052-2063
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yang Mingchuan¹,Wu Ximing²,He Yufeng¹,Li Xiuli¹,Yang Lumin¹,Song Tingting¹,Wang Fuming¹,Yang Chung S.³⁴^ORCID,Zhang Jinsong¹⁴^ORCID

Affiliation:

1. State Key Laboratory of Tea Plant Biology and Utilization, School of Tea & Food Science, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Anhui Agricultural University, Hefei, Anhui, China

2. Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, School of Biological and Food Engineering, Hefei Normal University, Hefei, Anhui, China

3. Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA

4. Joint International Research Laboratory of Tea Chemistry and Health Effects, State Key Laboratory of Tea Plant Biology and Utilization, School of Tea & Food Science, Anhui Agricultural University, Hefei, Anhui, China

Abstract

The EGCG polymers bind onto the cell surface and regulate multiple RAS components by reacting with the sulfhydryl groups on the ectodomains of transmembrane proteins, resulting in the apoptosis of CaCo2 cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO03795A

Reference42 articles.

1. Stability of Tea Polyphenol (−)-Epigallocatechin-3-gallate and Formation of Dimers and Epimers under Common Experimental Conditions

2. Model system-based mechanistic studies of black tea thearubigin formation

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4. EGCG-derived polymeric oxidation products enhance insulin sensitivity in db/db mice

5. The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer

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