Two novel fan-shaped trinuclear Pt(ii) complexes act as G-quadruplex binders and telomerase inhibitors-Reference-Cited by-同舟云学术

Two novel fan-shaped trinuclear Pt(ii) complexes act as G-quadruplex binders and telomerase inhibitors

Published:2020 Issue:27 Volume:49 Page:9322-9329
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Xu Cui-Xia¹²³⁴⁵,Liu Liu-Yi⁶⁷⁸⁹⁵^ORCID,Lv Bei¹²³⁴⁵^ORCID,Zhao Hao-Yu¹²³⁴⁵,Cao Qian⁶⁷⁸⁹⁵^ORCID,Zhai Teng¹⁰¹¹¹²¹³^ORCID,Mao Zong-Wan⁶⁷⁸⁹⁵^ORCID

Affiliation:

1. Jiangsu Key Laboratory for Biofunctional Molecules

2. College of Life Science and Chemistry

3. Jiangsu Second Normal University

4. Nanjing 211222

5. China

6. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry

7. School of Chemistry and Chemical Engineering

8. Sun Yat-Sen University

9. Guangzhou 510275

10. School of Materials Science and Engineering

11. Nanjing University of Science and Technology

12. Nanjing 210094

13. PR China

Abstract

Two new fan-shaped trinuclear Pt(ii) complexes stabilize human telemetric G-quadruplex (GQ) selectively and intercalate into the large groove of antiparallel GQ.

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

Fundamental Research Funds for the Central Universities

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT01767A

Reference35 articles.

1. Physiological relevance of telomeric G-quadruplex formation: a potential drug target

2. Prevalence of quadruplexes in the human genome

3. Hit Identification of a Novel Dual Binder forh-telo/c-mycG-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement

4. Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

5. Quantitative visualization of DNA G-quadruplex structures in human cells

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