Sulfonated, oxidized pectin-based double crosslinked bioprosthetic valve leaflets for synergistically enhancing hemocompatibility and cytocompatibility and reducing calcification

Author:

Hu Mengyue1,Peng Xu12,Shi Shubin1,Wan Chang1,Cheng Can1,Lei Ningning1,Yu Xixun1ORCID

Affiliation:

1. College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, P. R. China

2. Experimental and Research Animal Institute, Sichuan University, Chengdu 610065, P. R. China

Abstract

The synergistic strategy of sulfonated, oxidized pectin and quercetin can enhance the BVLs’ mechanical properties and also endow BVLs with excellent hemocompatibility, anti-inflammatory, anti-calcification, and pro-endothelialization.

Funder

National Key Research and Development Program of China

Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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