Azogabazine; a photochromic antagonist of the GABAAreceptor
Author:
Affiliation:
1. Department of Chemistry
2. University College London
3. London
4. UK
5. Department of Neuroscience
6. Physiology & Pharmacology
7. Pfizer Worldwide Medicinal Chemistry
8. Neuroscience and Pain Research Unit
9. Cambridgeshire
Abstract
The design and synthesis of Azogabazine is described, which is shown to act as a highly potent, photoswitchable antagonist of the GABAAreceptor.
Funder
Pfizer UK
Biotechnology and Biological Sciences Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01101B
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