Direct readout protonophore induced selective uncoupling and dysfunction of individual mitochondria within cancer cells

Author:

Bobba Kondapa Naidu1234,Binoy Anupama5674,Koo Seyoung891011,Nedungadi Divya5674,Podder Arup1234,Sharma Amit891011,Mishra Nandita5674ORCID,Kim Jong Seung891011ORCID,Bhuniya Sankarprasad1234ORCID

Affiliation:

1. Amrita Centre for Industrial Research and Innovation

2. Amrita School of engineering

3. Coimbatore

4. India

5. School of Biotechnology

6. Amrita Vishwa Vidyapeetham

7. Kollam

8. Department of Chemistry

9. Korea University

10. Seoul 02841

11. South Korea

Abstract

Endogenous H2S-stimulated protonophores released from MitoDP are a vanguard in creating mitochondria-targeted therapies for reducing mitochondrial activity in cancer cells.

Funder

Science and Engineering Research Board

Department of Science and Technology, Ministry of Science and Technology

University Grants Commission

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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