Irreversible covalent modification of type I dehydroquinase with a stable Schiff base-Reference-Cited by-同舟云学术

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Irreversible covalent modification of type I dehydroquinase with a stable Schiff base

Published:2015 Issue:3 Volume:13 Page:706-716
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tizón Lorena¹²³⁴,Maneiro María¹²³⁴,Peón Antonio¹²³⁴,Otero José M.⁵²³⁴,Lence Emilio¹²³⁴,Poza Sergio¹²³⁴,van Raaij Mark J.⁶⁷⁸⁴,Thompson Paul⁹¹⁰¹¹¹²¹³,Hawkins Alastair R.⁹¹⁰¹¹¹²¹³,González-Bello Concepción¹²³⁴

Affiliation:

1. Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS)

2. Universidad de Santiago de Compostela

3. 15782 Santiago de Compostela

4. Spain

5. Departamento de Bioquímica y Biología Molecular and CIQUS

6. Departamento de Estructura de Macromoléculas

7. Centro Nacional de Biotecnología (CSIC)

8. 28049 Madrid

9. Institute of Cell and Molecular Biosciences

10. Medical School

11. University of Newcastle upon Tyne

12. Newcastle upon Tyne NE2 4HH

13. UK

Abstract

Structural and computational studies carried out with two epoxides provide insight into the irreversible inhibition of type I dehydroquinase.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB01782J

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4. DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes

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