Cu(i) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action-Reference-Cited by-同舟云学术

Cu(i) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action

Published:2021 Issue:5 Volume:50 Page:1845-1865
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Sequeira Diogo¹²³⁴⁵,Baptista Pedro V.¹²³⁴⁵^ORCID,Valente Ruben¹²³⁴⁵^ORCID,Piedade M. Fátima M.⁶⁷⁸⁹⁵,Garcia M. Helena⁶⁷⁸⁹⁵,Morais Tânia S.⁶⁷⁸⁹⁵^ORCID,Fernandes Alexandra R.¹²³⁴⁵^ORCID

Affiliation:

1. UCIBIO

2. Departamento de Ciências da Vida

3. Faculdade de Ciências e Tecnologia

4. Universidade Nova de Lisboa

5. Portugal

6. DQB-FCUL

7. Departamento de Química e Bioquímica

8. Faculdade de Ciências

9. Universidade de Lisboa

Abstract

Cu(i) antiproliferative and cytostatic effect in ovarian cancer cells. Induction of reactive oxygen species which cause DNA damage and changes in protein folding triggering apoptotic and autophagic cell death.

Funder

Ministério da Ciência, Tecnologia e Ensino Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D0DT03566A

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