Multibarrier-penetrating drug delivery systems for deep tumor therapy based on synergistic penetration strategy

Author:

Zhang Hui-Feng1ORCID,Yu Huan1,Pan Shuang-Xue1,Zhang Chuang1,Ma Ying-Hui1,Zhang Yan-Fei1,Zuo Li-Li2,Hao Cheng-Yi1,Lin Xiao-Ying1,Geng Hao1,Wu Di1,Mu Shang-Qiang3,Yu Wei-Lun4,Shi Nian-Qiu15

Affiliation:

1. School of Pharmacy, Jilin Medical University, China

2. School of public health, Jilin Medical University, China

3. Affiliated hospital of Jilin Medical University, China

4. School of Bioengineering, Jilin Medical University, China

5. College of Pharmaceutical Sciences, Yanbian University, China

Abstract

We co-modified R9 and iNGR on the liposome surface to obtain Lip-mbPDS. The penetration of Lip-mbPDS into multiple biointerfaces has enabled it to demonstrate good anti-tumor ability for CD13-positive HT1080 cells both in vivo and ex vivo.

Funder

National Natural Science Foundation of China

Jilin Scientific and Technological Development Program

Education Department of Jilin Province

Publisher

Royal Society of Chemistry (RSC)

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