Optimization and multigram scalability of a catalytic enantioselective borylative migration for the synthesis of functionalized chiral piperidines-Reference-Cited by-同舟云学术

Optimization and multigram scalability of a catalytic enantioselective borylative migration for the synthesis of functionalized chiral piperidines

Published:2016 Issue:20 Volume:14 Page:4739-4748
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kim You-Ri¹²³⁴⁵,Hall Dennis G.¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. 4-010 Centennial Centre for Interdisciplinary Science

3. University of Alberta

4. Edmonton

5. Canada

Abstract

A systematic optimization of a Pd-catalyzed enantioselective borylative migration of an alkenyl nonaflate derivative of the simple precursor, N-Boc-4-piperidone, was achieved.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00685J

Reference47 articles.

1. Synthesis of piperidines

2. Indolizidine and quinolizidine alkaloids

3. Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework

4. Rings in Drugs

5. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

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